New research further debunks any link between measles vaccine and autism

In Uncategorized on September 9, 2008 at 11:16 am


AP Medical Writer

WASHINGTON (AP) _ New research further debunks any link between measles vaccine and autism, work that comes as the nation is experiencing a surge in measles cases fueled by children left unvaccinated.

Years of research with the measles, mumps and rubella vaccine, better known as MMR, have concluded that it doesn’t cause autism. Still, some parents’ fears persist, in part because of one 1998 British study that linked the vaccine with a subgroup of autistic children who also have serious gastrointestinal problems. That study reported that measles virus was lingering in the children’s bowels.

Only now have researchers rigorously retested that finding, taking samples of youngsters’ intestines to hunt for signs of virus with the most modern genetic technology. There is no evidence that MMR plays any role, the international team _ which included researchers who first raised the issue _ reported Wednesday.

“Although in fact there was evidence that this vaccine was safe in the bulk of the population, it had not been previously assessed with respect to kids with autism and GI complaints,” said Dr. W. Ian Lipkin of Columbia University College of Physicians and Surgeons, who led the work published in PLoS One, the online journal of the Public Library of Science.

“We are confident there is no link between MMR and autism,” Lipkin said.

Added co-author Dr. Larry Pickering of the Centers for Disease Control and Prevention: “I feel very certain that it is a safe vaccine.”

Measles, a highly infectious virus best known for its red skin rash, once routinely sickened thousands of children a year and killed hundreds, until childhood vaccinations made it a rarity in this country. But so far this year, the U.S. has counted 131 measles cases, the most in a decade. Most patients were unvaccinated. Some were infants too young for their first MMR shot, but nearly half involved children whose parents rejected vaccination, the CDC reported last month.

No one knows just how many autism patients also suffer gastrointestinal disorders, pain that they may not be able to communicate. But Lipkin said that by some estimates, up to a quarter may be affected.

The MMR fear was that the vaccine’s weakened measles virus somehow lodged in and inflamed intestines, allowing waste products to escape and reach the central nervous system, Lipkin said. So his team had two questions: Does measles virus really persist in children with both disorders and not other youngsters? And did vaccination precede the GI complaints which in turn preceded autism?

Researchers studied 25 children with both autism and GI disorders, and another 13 children with the same GI disorders but no neurologic problems. The youngsters _ the average age was 5 _ all were undergoing colonoscopies for their GI conditions anyway, allowing tissue samples to be tested for genetic traces of measles virus. All had been vaccinated at younger ages.

The tests uncovered traces of measles genetic material in the bowels of one boy with autism _ and one boy without autism. That doesn’t prove virus never temporarily lodged in more children, but it contradicts the earlier study that raised concern.

Nor was there a relationship with vaccine timing: Just five of the 25 autistic children had MMR precede GI complaints that in turn preceded autism symptoms.

Researchers consulted some prominent vaccine critics in designing the study. California advocate Rick Rollens praised the work but said it didn’t eliminate other vaccine concerns that deserve similar study. Meanwhile, he said it should draw much-needed attention to the suffering of patients like his son, who has both autism and GI disorders.

“No longer can mainstream medicine ignore the parents’ claims of significant GI distress,” he said.

  1. This study does not prove in any way that the MMR vaccine is safe – regardless of the high spirited reporting that followed its release.

    There needs to be an internationally controlled safety study done to ensure that parents feel confident that nothing is going to happen to their children if they are vaccinated.

    It is not the researchers, the supporting physicians, or the clinicians that have to live with the effects of an unsafe pharma product. It is the children who receive it and their parents, so until a comprehensive safety study is designed and carried out, we will continue to have parents refusing to vaccinate their children.

  2. re: “…so until a comprehensive safety study is designed and carried out, we will continue to have parents refusing to vaccinate their children.”

    Fixed that fer ya:

    “…so until a comprehensive safety study is designed and carried out that proves that I am right,we will continue to scare parents into refusing to vaccinate their children.”

  3. 11:38 you are either a physician or a pharma company employee to make a stupid bloody comment like that. You should read the following:

    Medication Errors Injure 1.5 Million People and Cost Billions of Dollars Annually;
    Report Offers Comprehensive Strategies for Reducing Drug-Related Mistakes (Institute of Medicine of the National Academies – Report from 2006)

    I am not trying to scare anybody. All I am saying is that an international study should be initiated that puts an end to the safety concerns pertaining to the MMR vaccine that many parents have.

    If you are into just vaccinating children without the proper safety due diligence being conducted on the product being prescribed, well then, you must not be as smart as you hoped your comment might make you seem.

  4. What going at van neste sq? theyre filming something there, on my way home on the bus I saw a camera or 2, some actors, those giant white screens to reflect the light, and other personnel.
    And on the bus this AM I saw truck for food service that was setting up.

    whats going on?

  5. 9:46 AM –

    Re: 11:38 you are either a physician or a pharma company employee to make a stupid bloody comment like that.

    I am neither.
    I have no dog in this fight.

    I just find it fascinating when apparently well educated rational people persist in believing a reasonably believable position EVEN AFTER THE POSITION HAS BEEN PROVEN TO BE UNTRUE.
    Just because a thing seems reasonable and just because a thing may be plausible doesn’t always make it so.

    So you can keep calling me names, but you might be happier going back into your basement and re-arranging your “Grassy Knoll” photos and viewing your “World Trade Center Demolition” videos.

  6. Question, why an “international” study?

    American medicine is tightly controlled by the American government. American pharma testing is generally stricter than any European or International medical boards. I’m sure if there was an international study out there the rallying cry would be “we need an American study, strict American standards”

    This language the “internationally controlled safety study” sounds so reasonable, but it is intentionally misleading. They ask for international studies because they know each vaccine is rigorously studied in the US before being added to the vaccine regime. And they ask for a controlled study, knowing that a full controlled study on the specific vaccine (where it is tested singly for safety) would never happen, because it is medically irresponsible to keep vaccines (that have already been proven safe) from children.

    Right now parents who keep their children unvaccinated are freeloading off the vaccinations of other children. The unvaccinated face a much lower risk of getting LIFE THREATENING DISEASES (lest we forget that measles mumps and rubella are not just the common cold or chicken pox) because vaccination rates remain high enough. But as vaccination rates drop the penumbra of protection fades, this year has already seen more measles cases in the US than anytime in the past decade. Parents talk about not risking their child’s safety by getting them vaccinated, but even if for argument’s sake we posit that there may be some connection between vaccines and the very serious neurological disorders on the Autism spectrum, getting life-threatening measles is still a much more probable result of being unvaccinated than developing a Autism spectrum disorder.

    And before you attack me (and anyone else who disagrees with you) as a tool of the pharma industry or someone bent on suppressing the “real” information because of this issue. You should remember that the lead doctor in the initial study that made the GI-MMR-Autism link (a study that was of the same size and scope of the test in this article, not the international controlled study you claim to want to disprove it) is currently facing an inquiry for serious ethical and medical misconduct charges and the results of the study have been retracted. When he did his research he had accepted a large sum of his funding from a group suing the British government over the MMR vaccine, and some of the children in the study were recruited from these (biased) parties. (Additionally he took a number of medical risks with some of these children, risks that caused damage and required additional medical care to fix.)The medical journal in which the study was printed and 10 of the 12 co-authors of the paper issued a retraction of the findings of the study saying:

    “We wish to make it clear that in this paper no causal link was established between (the) vaccine and autism, as the data were insufficient. However the possibility of such a link was raised, and consequent events have had major implications for public health. In view of this, we consider now is the appropriate time that we should together formally retract the interpretation placed upon these findings in the paper, according to precedent”

    Look Autism spectrum disorders are a serious issue, we need to stop chasing ghosts and bad science and start coming together to provide much needed funding for services that help the children (and the growing population of adults) affected.

    Sorry for the long post.

  7. I am going to be just as long in my comments so I apologize in advance:

    Re: American medicine is tightly controlled by the American government. American pharma testing is generally stricter than any European or International medical boards

    Well, if that is the case maybe you should check out the number of lawsuits that are currently before the courts in the US versus the courts in the EU (individual member states or the EU collectively) pertaining to the numerous pharma products that resulted in death or serious injury to innocent patients because the pharma companies were in a rush to get those products to market, because to report various findings in the initial studies might have delayed their market launch and because the FDA/DDMAC (consumer pharmaceutical product division of the FDA) did not carry out the required proper due diligence pertaining to the approval of these products.

    Let me go back a few years and share some personal experience. I am the president/ceo of an advertising/pr agency in the city. One product that I actually worked on was being prescribed for ulcerative colitis. When my agency started working on this product, its market share was less than 0.43%, which in pharmaceutical terms is a disaster.

    Anybody that has ulcerative colitis will now what I am talking about, but the early symptoms of this disease include runny, painful diarrhea. A company that does not exist anymore, having merged with a larger company in the late 1990’s, developed this product and was in such a rush to get it to market that they covered up the side effects of the product by informing physicians that their patients were actually suffering the consequences of their disease. The major side effect of this product was runny, painful diarrhea, sounds familiar? Well, the FDA, which approved all the studies for this brand, slapped the pharma company with a massive fine and informed it that all its promotional materials had to reflect the fact that further testing had to be carried out to determine what brought on this side effect which was very difficult to determine from the actual disease symptoms. The pharma company refused to carry out the required testing and shelved the brand, allowing it to deteriorate to its ridiculously low market share.

    A new biotech company from the UK wanted to get into the gastroenterology market place because it had products in its pipeline for the treatment of Crohns Disease and so it bought this ulcerative colitis product. Hence I was brought into the fold to set up the market and prepare it for a relaunch to the gastroenterology profession. At first it appeared to be mission impossible, but armed with all the studies conducted on this product, both US and International, I spent one long weekend going through the data with a fine tooth comb.

    The burning question in my mind related to its 0.43% market share – why were physicians still prescribing this product and who were they prescribing it to – I found the answer at 7:00 a.m. on a Sunday morning, just as my mates were heading out to play golf and I was settling into my home office here in Ridgewood.

    Ulcerative colitis affects the colon and it is a chronic disease. People who have UC become depressed, it certainly ruins a lot of clothing and it makes long road trips to the country not possible, unless patients are on a treatment regime that works. Most UC patients suffer from what is known as pan-colitis which basically means that the whole colon is affected. Some patients suffer what is known as distal colitis which basically means that the left side of the colon is the only part of the organ that is affected.

    What I found in all the study data relating to this product highlighted that the highest efficacy levels, with the lowest side effect levels were experienced by those patients with distal colitis. I aligned the data, drew charts, made copies of everything and represented them to my UK biotech clients the following Wednesday morning, when I called a tactical meeting at my office in New York.

    From this meeting, we conducted physician-based focus groups and presented what we had found and asked them, based on what they now knew about this product, would they be willing to prescribe this product again, which they all had experience (very bad experience) with and the general answer was yes! My agency grew the brand from its miserable 0.43% to an approximate market share level of 37.6%.

    The point that I am making is the fact that pharmaceutical products have to be efficacious, but most of all they have to be safe and if there is data out there that show that safety is not an issue then physicians will prescribe it, patients or their caregivers will request it and everybody will reap the rewards, the pharma company included. But if there is not specific safety study available, because none was ever conducted or it was tarnished, well then their needs to be a joint effort to put patient/caregiver minds at ease and to make the physician’s job easier and in relation to the MMR vaccine this can only be achieved by conducting an internationally comprehensive safety study. At current rates, a large number of parents are not convinced that the MMR vaccine is 100% safe from autism, hence the rapid growth in the contracting of the measles virus, not only in the US but also in the EU, due to the non-vaccination of children.

    This study will cost money – are our children’s lives not worth it?

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: